Methylation Support – 5-MTHF/B12 MC2000 (60)

Original price was: $27.85.Current price is: $25.07.

Combines a proprietary form of folic acid with Methylcobalamin, the active form of vitamin B12, to support heart and cellular health, methylation and healthy pregnancy.

SKU: 020087E.060 Category: Tag:


5-MTHF/B12 MC 2000 contains 1000 mg per serving of each folic acid and the active form of B12. Quatrefolic® from Gnosis is a new generation of folic acid. It represents a breakthrough in folate supplementation with regard to an active, stable, and highly bioavailable form when compared to folic acid and the methyl derivative folate. Quatrefolic® provides folate in the (6S)-5-methyltetrahydrofolate form which is easily utilized and stored in the body.* The methylcobalamin form of B12 is the active form and does not need to be converted.

5-MTHF / B12 MC 2000 combines the most active, stable, and highly bioavailable forms of folate and vitamin B12 (methylcobalamin)

5-MTHF / B12 MC 2000 is:

  • The most stable, bioavailable and active form of folate and
    vitamin B12
  • Recommended for methylation, cellular health, and child-bearing
  • A preferred form of folate for the support of homocysteine
    management, heart health and nerve function*
  • Vegetarian
  • Gluten and soy free
  • Made with non-gmo ingredients

Methylcobalamin is the active form of B12. It does not have to be
converted so it starts working right away. It’s also the form used to make
methionine synthase, an enzyme that converts homocysteine into
methionine. In fact, 80% of B12 in the plasma is in the methylcobalamin

Folate, Vitamin B12 and Pregnancy
Taking folate before and during pregnancy supports the development of a
healthy brain and spinal cord.* It is recommended that folate consumption begin within the first 3-4 weeks of pregnancy so it is important to have it in your system during those early stages when the baby’s brain
and spinal cord are developing.* Folate bypasses the need for enzymatic
activation making it readily available to be used by the body. The active
form of Vitamin B12 (methylcobalamin) has been included because the
recommended dietary allowance of vitamin B12 is higher for pregnant
women. Vitamin B12 is essential for the functioning of the nervous
system and for the production of red blood cells.* Studies have shown
that women with low levels of B12 put both themselves and baby at risk
of health problems.*

Importance of Methylation
Methylation is the process of attaching methyl groups to a compound in
order to produce other compounds or to protect an existing compound
from damage. This process is important to good health and well-being as
it contributes to a wide variety of bodily functions such as:

  • Production of enzymes, hormones, neurotransmitters, antibodies,
    vitamins and cell membranes*
  • Energy production, immune function, and detoxification*
  • Repairing and building DNA, brain activity and mood balancing*
  • Healthy inflammatory response, homocysteine management and
    neurological function*
  • Folate and vitamin B12 are essential cofactors in the methylation

About Folate
Folate is a member of the B vitamin family and is necessary for methylation reactions in that it is required for the donation or transfer of methyl groups and for dontating its own methyl group to homocycteine in order to produce methionine for the production of SAMe, the principle methylating agent in the body. Folate is also required for healthy development of cells, brain function and protection from cell damage.*

Folate Inadequacy
Folate is normally found in a wide variety of foods. However, it is unstable and susceptible to oxidation and rapidly lose activity during food
processing, manufacturing and storage. Common folic acid supplements must be converted to folate by an enzyme called methylenetetrahydrofolate reductase in order for it to be absorbed and utilized by the body. Several conditions such as an enzyme defect, malabsorption, digestive system challenges and poor liver function can lead to a folate inadequacy. Lifestyle choices such as smoking, alcohol excess, eating disorders, low vegetable intake and chronic dieting such put people at risk of low folate levels. As a result, much of society has low levels of folate due to poor metabolism of folic acid from either food or supplements.

5-MTHF / B12 MC 2000 from DaVinci® Laboratories uses folate because it bypasses the need for enzymatic activation making it readily available to be used by the body.

Suggested Use: As a dietary supplement, take 1 capsule daily,
or as directed by your healthcare practitioner

Warning: If pregnant or nursing, consult your healthcare
practitioner before taking this product.